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Tech entrepreneur and longevity advocate Bryan Johnson has discontinued his use of rapamycin, a controversial anti-ageing drug, after concerns it may have accelerated ageing rather than reversed it. The 47-year-old millionaire, known for spending $2 million annually on cutting-edge treatments to slow ageing, revealed in a social media post that his team concluded the risks of lifelong rapamycin use outweighed its benefits. Johnson, who undertook what he described as "the most aggressive rapamycin protocol of anyone in the industry," admitted that he began experiencing skin infections, abnormal lipid levels, and elevated blood sugar—all potential side effects of the immunosuppressant. Concerns over unintended effects Rapamycin, originally developed to prevent organ transplant rejection, is not approved by the US Food and Drug Administration (FDA) for anti-ageing use. However, some longevity researchers have prescribed it off-label, citing studies that suggest it extends the lifespan of mice. Despite early optimism, Johnson revealed that after nearly five years of experimentation, the drug might have done more harm than good. Photo: X "Despite immense potential from preclinical trials, my team and I concluded that the benefits of lifelong rapamycin use do not justify its hefty side effects," he stated on X, formerly Twitter. He further cited research indicating that prolonged use could disrupt lipid metabolism, cause insulin resistance, and even increase cancer risks due to its impact on immune surveillance. Netflix documentary explores Johnson’s extreme anti-ageing journey The revelation came just ahead of the release of Netflix’s upcoming documentary, ‘Don’t Die: The Man Who Wants to Live Forever’, which follows Johnson’s relentless and often controversial quest to reverse ageing. View this post on Instagram A post shared by Bryan Johnson (@bryanjohnson_) Directed by Chris Smith (‘Fyre’, ‘100 Foot Wave’), the documentary provides an intimate look at Johnson’s extreme biohacking methods, which include: Plasma transfusions from his teenage son Fat transfers Daily intake of 50+ supplements Gene therapy experiments According to the film’s description, "This documentary dives into the controversial wellness practices one man is using to maintain youth and vitality, and the effect this journey has on himself and those around him." What’s next for Johnson? While Johnson has now dropped rapamycin from his regimen, he continues to explore other longevity interventions, stating that he remains committed to finding effective ways to slow ageing. His approach, however, has sparked debate among medical professionals, with some cautioning that extreme longevity protocols could pose unknown long-term risks. For now, Johnson’s latest setback raises critical questions about the effectiveness and safety of longevity treatments—and whether the pursuit of eternal youth could come with unexpected consequences.
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